Macrocycle Synthesis

This volume provides a practical introduction to the synthesis of macrocyclic compounds, which can be tailored to function as selective receptors for ions and neutral molecules. Initial chapters address the synthesis of nitrogen-, sulfur-, and oxygen-containing macrocycles (e.g. benzo- and chiral crown ethers, cryptands, and torands). Subsequent chapters examine synthesis and elaboration of calixarenes, spherands, hemi-spherands, and calix-spherands, with a final chapter on the metal-templated synthesis of catenanes. There is a balance between 'classical ligands and more elaborate and recently defined macrocycles and many of the protocols are suitable for inclusion in advanced undergraduate classes. . Macrocycle synthesis: a practical approach is an essential and detailed guide for all those engaged in the synthesis of macrocyclic compounds and interested in their coordination chemistry. It will appeal to the specialist and non-specialist alike, and should serve as an ideal introduction and companion for newcomers to the field.