Infantas de Portugal, Rainhas em Espanha

From 1165 until 1816 eleven Princesses of Portugal were Queens of Spain by marriage. Beatrice, whose marriage to king John I of Castile led to the 1383–1385 Crisis (Portuguese Interregnum) in which a good part of the Portuguese prevented the annexation of Portugal by Castille. Joan, the second wife of King Henry IV of Castile, provoked much criticism in the court as she allegedly had many lovers. Isabella the Catholic and Philip II both had Portuguese mothers. Maria Isabel of Portugal, second wife of Ferdinand VII of Spain, founded the Museo del Prado.